201 research outputs found

    Putting the “Joy” in joint attention: affective-gestural synchrony by parents who point for their babies

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    Despite a growing body of work examining the expression of infants’ positive emotion in joint attention contexts, few studies have examined the moment-by-moment dynamics of emotional signaling by adults interacting with babies in these contexts. We invited 73 parents of infants (three fathers) to our laboratory, comprising parent-infant dyads with babies at 6 (n = 15), 9 (n = 15), 12 (n = 15), 15 (n = 14), and 18 (n = 14) months of age. Parents were asked to sit in a chair centered on the long axis of a room and to point to distant dolls (2.5 m) when the dolls were animated, while holding their children in their laps. We found that parents displayed the highest levels of smiling at the same time that they pointed, thus demonstrating affective/referential synchrony in their infant-directed communication. There were no discernable differences in this pattern among parents with children of different ages. Thus, parents spontaneously encapsulated episodes of joint attention with positive emotion

    Nebraska Intellectual Freedom Manual

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    Much has changed in libraries and society since the publication of the 2004 revision of the Nebraska Library Association Intellectual Freedom Manual. The consensus of the current members of the Nebraska Library Association round table on Intellectual Freedom (NLA IF) was not to just revise the former manual, but to create an entirely new edition. In doing so, the authors have addressed a number of new issues. The intention was to keep it relatively brief but still useful. Readers should be able to read sections independent of one another for quick reference on topics of interest. For readers of the electronic version, there are many hyperlinks included. Though this is a new edition, the introduction to the 2004 revision still applies: As librarians, we are all concerned with the concept of intellectual freedom. It is our professional obligation to provide varied forms of information that meet the varied interests and needs of our community members. It is also our professional obligation to oppose the efforts of those who would attempt to monitor, challenge, change, or remove the materials of choice in our society. This handbook provides access to relevant resources for all librarians who may face a censorship challenge. Included are interpretations from the Library Bill of Rights, policies and procedures, examples of useful forms, and a list of library related organizations that may be contacted for further information. For additional information, readers are encouraged to consult the latest edition of the American Library Association (ALA) Intellectual Freedom Manual, as well as manuals from other U.S. states\u27 library organizations. A companion to the ALA manual is available online at http://www.ifmanual.org/ . For current information about intellectual freedom issues in Nebraska, visit the NLA IF website.https://digitalcommons.unl.edu/zeabook/1044/thumbnail.jp

    Nebraska Intellectual Freedom Manual

    Get PDF
    Much has changed in libraries and society since the publication of the 2004 revision of the Nebraska Library Association Intellectual Freedom Manual. The consensus of the current members of the Nebraska Library Association round table on Intellectual Freedom (NLA IF) was not to just revise the former manual, but to create an entirely new edition. In doing so, the authors have addressed a number of new issues. The intention was to keep it relatively brief but still useful. Readers should be able to read sections independent of one another for quick reference on topics of interest. For readers of the electronic version, there are many hyperlinks included. Though this is a new edition, the introduction to the 2004 revision still applies: As librarians, we are all concerned with the concept of intellectual freedom. It is our professional obligation to provide varied forms of information that meet the varied interests and needs of our community members. It is also our professional obligation to oppose the efforts of those who would attempt to monitor, challenge, change, or remove the materials of choice in our society. This handbook provides access to relevant resources for all librarians who may face a censorship challenge. Included are interpretations from the Library Bill of Rights, policies and procedures, examples of useful forms, and a list of library related organizations that may be contacted for further information. For additional information, readers are encouraged to consult the latest edition of the American Library Association (ALA) Intellectual Freedom Manual, as well as manuals from other U.S. states\u27 library organizations. A companion to the ALA manual is available online at http://www.ifmanual.org/ . For current information about intellectual freedom issues in Nebraska, visit the NLA IF website.https://digitalcommons.unl.edu/zeabook/1044/thumbnail.jp

    A prospective cohort study measuring cost-benefit analysis of the Otago Exercise Programme in community dwelling adults with rheumatoid arthritis.

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    BACKGROUND: Falls are one of the major health problems in adults with Rheumatoid Arthritis (RA). Interventions, such as the Otago Exercise Programme (OEP), can reduce falls in community dwelling adults by up to 35%. The cost-benefits of such a programme in adults with RA have not been studied. The aims of this study were to determine the healthcare cost of falls in adults with RA, and estimate whether it may be cost efficient to roll out the OEP to improve function and prevent falls in adults living with RA. METHODS: Patients with Rheumatoid Arthritis aged ≥18 years were recruited from four rheumatology clinics across the Northwest of England. Participants were followed up for 1 year with monthly fall calendars, telephone calls and self-report questionnaires. Estimated medical cost of a fall-related injury incurred per-person were calculated and compared with OEP implementation costs to establish potential economic benefits. RESULTS: Five hundred thirty-five patients were recruited and 598 falls were reported by 195 patients. Cumulative medical costs resulting from all injury leading to hospital services is £374,354 (US540,485).Averageestimatedcostperfallis£1120(US540,485). Average estimated cost per fall is £1120 (US1617). Estimated cost of implementing the OEP for 535 people is £116,479 (US168,504)or£217.72(US168,504) or £217.72 (US314.34) per-person. Based on effectiveness of the OEP it can be estimated that out of the 598 falls, 209 falls would be prevented. This suggests that £234,583 (US338,116)savingscouldbemade,anetbenefitof£118,104(US338,116) savings could be made, a net benefit of £118,104 (US170,623). CONCLUSIONS: Implementation of the OEP programme for patients with RA has potentially significant economic benefits and should be considered for patients with the condition

    Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

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    Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts
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